The following are events related to the Global War On Terrorism (GWOT) that took place on this day.

2001

• Start of Operation Slipper in Afghanistan

2015

• Thomas Payne, Army, Sergeant First Class, is the recipient of the Congressional Medal of Honor for his actions on October 22, 2015.

Casualties on October 22:

• JOHNSON, JOHN PAUL – October 22, 2003
• WARD, JASON MAXWELL – October 22, 2003
• GADSDEN, JONATHAN EARL – October 22, 2004
• ALEXANDER, GEORGE THOMAS JR – October 22, 2005
• AGUIRRE, NATHANIEL AARON – October 22, 2006
• CREED, MATTHEW WALLACE – October 22, 2006
• MOCK, WILLSUN MARCUS – October 22, 2006
• ROGERS, NICHOLAS KEITH – October 22, 2006
• TAYLOR, DAVID GLADNEY JR – October 22, 2006
• CAMACHO, ANA MARIE SAN NICOLAS – October 22, 2007
• GRESHAM, GENESIA MATTRIL – October 22, 2007
• ROBLES, ADRIAN – October 22, 2008
• SIM, SAN – October 22, 2008
• TAYLOR, DEON LAMARR – October 22, 2008
• DOMEIJ, KRISTOFFER BRYAN – October 22, 2011
• HORNS, CHRISTOPHER ALEXANDER – October 22, 2011
• RIVERA, PAUL ANDREW – October 22, 2011
• WHITE, ASHLEY IRENE – October 22, 2011
• WHEELER, JOSHUA LLOYD – October 22, 2015