The following are events related to the Global War On Terrorism (GWOT) that took place on this day.

Casualties on September 22:

• STURINO, PAUL JOSEPH – September 22, 2003
• HARRIS, ADAM JOSEPH – September 22, 2004
• KOENIG, LANCE JACOB – September 22, 2004
• SMITH, BENJAMIN KENT – September 22, 2004
• SORAM, SKIPPER – September 22, 2004
• JONES, KEVIN MCCRAY – September 22, 2005
• MCLAUGHLIN, SCOTT PAUL – September 22, 2005
• SONODA, MIKE TAKESHI JR – September 22, 2005
• LANKFORD, JONATHAN MILES SR – September 22, 2007
• REEVES, JOSHUA HARRISON – September 22, 2007
• WATSON, DAVID LEE – September 22, 2007
• CARABALLO MORALES, ANDY – September 22, 2011
• ROBERTS, DION RASHUN – September 22, 2012
• GIBSON, JONATHAN SHELBY – September 22, 2013
• JONES, LANDON LE – September 22, 2013